Related Experiment Video
Updated: May 3, 2026
10:25
Real-time Bioluminescence Imaging of Notch Signaling Dynamics during Murine Neurogenesis
Published on: December 12, 2019
6.3K
Regulation of cadherin expression in nervous system development
Alicia F Paulson1, Maneeshi S Prasad2, Amanda Henke Thuringer3
1Division of Basic Biomedical Sciences; Sanford School of Medicine of The University of South Dakota; Vermillion, SD USA.
Cell Adhesion & Migration
|February 15, 2014
Summary
Classical cadherins regulate vertebrate nervous system development. Understanding their complex expression patterns and regulatory networks is crucial for grasping their roles in cell adhesion and development.
Area of Science:
- Developmental Biology
- Neuroscience
- Cell Biology
Background:
- Classical cadherins are vital cell adhesion molecules.
- Their expression patterns are complex during vertebrate nervous system development.
- Understanding cadherin regulation is key to understanding nervous system formation.
Purpose of the Study:
- To review current knowledge on regulatory mechanisms of classical cadherin expression.
- To link expression patterns to morphogenic and functional roles in the developing nervous system.
- To highlight the importance of understanding both upstream regulation and downstream effects of cadherins.
Main Methods:
- Literature review of existing research on cadherin expression and regulation.
- Analysis of spatial and temporal expression patterns in the vertebrate nervous system.
- Synthesis of information on signaling pathways influencing cadherin expression.
Main Results:
- Cadherin expression complexity correlates with developmental roles.
- Regulatory networks are not fully elucidated but involve multiple signaling pathways.
- Cadherins have roles beyond cell-cell adhesion, including non-adhesion processes.
Conclusions:
- Further research is needed to fully understand cadherin regulatory networks.
- Investigating upstream regulation and downstream effects is critical.
- Comprehensive understanding of cadherins is essential for developmental neuroscience.
Related Concept Videos
01:19Cadherins in Tissue Organization
3.5K
The cadherins are a superfamily of cell adhesion molecules comprising over 180 variants, with specific tissues expressing a particular combination of cadherin types. Cadherins generally exhibit homophilic binding; i.e., cadherins on one cell bind to cadherins of the same or closely related type on another cell. Thus, cells of the same type have a specific affinity to bind to each other and sort themselves into clusters to form tissues.
Cell Sorting During Development
Cell sorting plays an...
Cell Sorting During Development
Cell sorting plays an...
3.5K
01:25Structure of Cadherins
4.0K
The cadherins were one of the first cell adhesion molecules discovered; the term “cadherins” is based on their calcium-dependent adhering properties. The first cadherins discovered on the epithelial, neuronal, and placental cells were named E-cadherin, P-cadherin, and N-cadherin, respectively. These classical cadherins share sequence and structural similarities. Other cadherins, including those involved in cell signaling, are grouped into non-classical cadherins. This...
4.0K
01:24Regulation of Angiogenesis and Blood Supply
2.9K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
2.9K
01:23Catenins
2.2K
Catenins are characterized by multiple binding domains and dynamic structures that allow them to function as linker proteins in cell junction complexes. All catenins, except α-catenin, contain a characteristic protein sequence called the armadillo repeat and are therefore also called armadillo proteins.
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the...
Catenins in Cell Junctions
Catenins bind to cell adhesion molecules such as cadherins and link them to different cytoskeletal proteins depending on the type of cell junction. At the...
2.2K
01:51Determination
16.3K
During embryogenesis, cells become progressively committed to different fates through a two-step process: specification followed by determination. Specification is demonstrated by removing a segment of an early embryo, “neutrally” culturing the tissue in vitro—for example, in a petri dish with simple medium—and then observing the derivatives. If the cultured region gives rise to cell types that it would normally generate in the embryo, this means that it is specified. In...
16.3K
03:14Notch Signaling Pathway
4.6K
The Notch signaling pathway is a major intracellular signaling pathway that is highly conserved over a broad spectrum of metazoan species. It stands unique from other intracellular signaling mechanisms in animals because notch protein itself acts as the receptor as well as the primary signaling molecule.
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
The Notch gene came into the limelight in 1914 after the discovery that its mutation in Drosophila melanogaster leads to a serrated (or "notched") wing margin phenotype. It was not...
4.6K