Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Allergic Reactions02:06

Allergic Reactions

26.4K
Overview
26.4K
Asthma-I: Introduction01:29

Asthma-I: Introduction

3.6K
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
3.6K
Asthma I: Introduction01:28

Asthma I: Introduction

112
Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
112
Allergic Reactions: Anaphylaxis01:30

Allergic Reactions: Anaphylaxis

280
Anaphylaxis is a severe, life-threatening hypersensitivity reaction mediated by Immunoglobulin E (IgE) antibodies. When IgE binds to allergens, it triggers the release of mediators– histamine, leukotrienes, and prostaglandins from mast cells and basophils. These mediators cause vasodilation, edema, and inflammation, leading to various symptoms.The primary allergens causing anaphylaxis include food items (e.g., peanuts, shellfish), drugs (e.g., penicillin, asparaginase, corticotropin,...
280
Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

4.7K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
4.7K
Drugs Used in Upper Respiratory Disorders: Overview01:16

Drugs Used in Upper Respiratory Disorders: Overview

1.0K
Upper respiratory tract disorders, including viral infections and allergic rhinitis, cause significant discomfort and disrupt daily life. Managing these conditions involves a variety of drugs, such as antihistamines, intranasal steroids, decongestants, antitussives, expectorants, and mucolytics. Specific examples of drugs in each category are provided.
Antihistamines (e.g., Benadryl) block histamines from binding. Histamines are chemicals released during an allergic reaction in the body. As a...
1.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Occupational Rhinitis.

Immunology and allergy clinics of North America·2025
Same author

History of pollutant adjuvants in respiratory allergy.

Frontiers in allergy·2024
Same author

Relationships between GABA, glutamate, and GABA/glutamate and social and olfactory processing in children with autism spectrum disorder.

Psychiatry research. Neuroimaging·2023
Same author

Trigeminal Function in Sino-Nasal Health and Disease.

Biomedicines·2023
Same author

Seroprevalence of SARS-CoV-2 Among Firefighters/Paramedics in San Francisco, CA.

Journal of occupational and environmental medicine·2021
Same author

Assessment of Methylene Chloride-Related Fatalities in the United States, 1980-2018.

JAMA internal medicine·2021

Related Experiment Video

Updated: May 3, 2026

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence
06:08

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence

Published on: September 22, 2023

2.7K

Occupational irritant and allergic rhinitis.

Dennis Shusterman1

  • 1Division of Occupational and Environmental Medicine, University of California, San Francisco, CA, USA, dshusterman@sfghoem.ucsf.edu.

Current Allergy and Asthma Reports
|February 15, 2014
PubMed
Summary

Occupational irritants and allergens can harm the upper airway, affecting functions like filtration and sensation. This can lead to conditions such as rhinitis and potentially asthma, impacting overall respiratory health.

Area of Science:

  • Environmental Health
  • Respiratory Medicine
  • Toxicology

Background:

  • The upper airway (nares to larynx) performs vital functions: sensation, air conditioning, filtration, and communication.
  • Olfactory and trigeminal nerves act as sentinels at the respiratory tract's entry point.
  • Sensory irritation is frequently reported in "problem buildings" and from industrial chemical exposures.

Purpose of the Study:

  • To review the health effects of occupational irritants and allergens on the upper airway.
  • To discuss the "unified airway" model where upper airway issues may precede asthma.
  • To highlight the spectrum of sinonasal conditions linked to workplace exposures.

Main Methods:

  • Literature review of occupational irritant and allergen effects on the upper airway.

More Related Videos

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

1.8K
Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

3.9K

Related Experiment Videos

Last Updated: May 3, 2026

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence
06:08

Author Spotlight: Advancing Allergic Rhinitis Research with Multicolor Immunofluorescence

Published on: September 22, 2023

2.7K
Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis
03:40

Acupoint Catgut Embedding Therapy in Traditional Chinese Medicine for Managing Allergic Rhinitis

Published on: December 20, 2024

1.8K
Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber
08:47

Symptom Assessment of Patients with Allergic Rhinitis Using an Allergen Exposure Chamber

Published on: March 3, 2023

3.9K
  • Analysis of the "unified airway" hypothesis in pathogenesis.
  • Compilation of reported sinonasal health outcomes.

    • Main Results:

    • Irritants and allergens can impair upper airway functions, causing airflow obstruction and hypersecretion.
    • Conditions like rhinitis, sinusitis, and olfactory dysfunction are linked to these exposures.
    • The review covers a range of effects, from sensory irritation to sinonasal cancer.

    Conclusions:

    • Occupational exposures pose significant risks to upper airway health.
    • The "unified airway" model suggests a connection between upper and lower airway diseases.
    • Prompt recognition and management of upper airway symptoms are crucial for preventing severe outcomes.