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Large cystic-based gastrointestinal stromal tumor: A case report
Xinqi Chen1, Huizeng Lv1, Wenhai Zhang1
1Department of Digestive Surgery, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510700, P.R. China.
Oncology Letters
|February 15, 2014
Summary
A large gastric gastrointestinal stromal tumor (GIST) presented as a cystic mass. Surgical removal was successful, with no recurrence after 12 months, highlighting effective GIST management.
Area of Science:
- Gastroenterology
- Surgical Oncology
- Pathology
Background:
- Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract.
- Large GISTs can present as complex cystic masses, posing diagnostic challenges.
- Early and accurate diagnosis is crucial for effective patient management and prognosis.
Purpose of the Study:
- To report a rare case of a large cystic gastric GIST.
- To describe the diagnostic and surgical management of this unusual presentation.
- To emphasize the importance of immunohistochemistry in GIST diagnosis.
Main Methods:
- Case report of a 60-year-old male with abdominal distension.
- Diagnostic imaging including abdominal sonogram and contrast-enhanced computed tomography (CT).
- Surgical exploration (laparotomy) with pathological and immunohistochemical analysis (CD117, CD34).
Main Results:
- A huge cystic-based tumor with solid components was identified in the left upper quadrant, originating from the posterior gastric wall.
- The tumor contained approximately 3,500 ml of fluid and exhibited a mix of polygonal and spindle cells.
- Immunohistochemistry confirmed the diagnosis of GIST, with positive staining for CD117 and CD34.
Conclusions:
- Gastric gastrointestinal stromal tumors can present as large cystic masses, requiring comprehensive diagnostic evaluation.
- Surgical resection is an effective treatment for gastric GISTs.
- Complete resection and vigilant follow-up are essential to prevent recurrence and metastasis.
