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Updated: May 3, 2026

A Modular Workflow for Quantitative, Structural and Functional Analysis of Leptospira Biofilms
Published on: December 19, 2025
Severe leptospirosis with multiple organ failure successfully treated by plasma exchange and high-volume
Vincent Bourquin1, Belén Ponte1, Bernard Hirschel2
1Service de Néphrologie, Département de Médecine Interne, Hôpitaux Universitaires de Genève, 1205 Genève, Switzerland.
Abstract:
Background. Leptospirosis is a spirochetal zoonosis with complex clinical features including renal and liver failure. Case report. We report the case of a Swiss fisherman presenting with leptospirosis. After initial improvement, refractory septic shock and severe liver and kidney failure developed. The expected mortality was estimated at 90% with clinical scores. The patient underwent plasma exchanges and high-volume hemofiltration (HVHF) with complete recovery of hepatic and kidney functions. Discussion. Plasma exchanges and HVHF may confer survival benefit on patients with severe leptospirosis, refractory septic shock, and multiple-organ failure.
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