Differences in open state of NBA-modified cardiac Na+ channels

¹Physiological Institute, University Freiburg, Federal Republic of Germany.

|January 1, 1988

Abstract:

Patch clamp recordings from neonatal cardiac Na+ channels treated with N-bromoacetamide (NBA, 5-50 X 10- mol/l) showed modified Na+ channel activity. By chemical removal of inactivation, repetitive openings with an increased life time and burst-like activity occurred. NBA-modified Na+ channels differ in life time and may attain either a slightly (mean open time 3.1 +/- 0.2 ms) or a strongly (mean open time 15.2 +/- 1.4 ms) prolonged open state. This strongly suggests a heterogeneous population of NBA-modified Na+ channels in newborn rat cardiocytes.

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Differences in open state of NBA-modified cardiac Na+ channels

Abstract:

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