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Related Concept Videos

Healing II: Complications01:24

Healing II: Complications

37
Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...
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Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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Overview of Regeneration and Repair01:19

Overview of Regeneration and Repair

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Regeneration and repair processes are critical in healing damages caused by injury, disease, and aging. In regeneration, the damaged tissue is entirely replaced with new growth that restores the original architecture and function. In contrast, tissue repair usually results in a fixed tissue architecture involving scar formation. Scars generally do not reestablish tissue function and may also exhibit structural abnormalities at the injury site.
Regeneration
All animals have varying degrees of...
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Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

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The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
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Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Related Experiment Video

Updated: May 3, 2026

Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue
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Isolation, Culture, and Characterization of Primary Dermal Fibroblasts from Human Keloid Tissue

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Update on Keloid Management: Clinical and Basic Science Advances.

Martha H Viera1, Alejandra C Vivas1, Brian Berman1

  • 1Department of Dermatology and Cutaneous Surgery, University of Miami Miller School of Medicine , Miami, Florida.

Advances in Wound Care
|February 15, 2014
PubMed
Summary
This summary is machine-generated.

Keloids are abnormal scars causing excessive fibrosis and pain. Novel agents like interferon alpha and imiquimod show promise in preventing keloid recurrence after treatment.

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Area of Science:

  • Dermatology and wound healing research.
  • Fibroproliferative disorders and scar management.

Background:

  • Keloids are benign fibroproliferative lesions characterized by excessive collagen deposition, extending beyond wound margins.
  • Symptoms include pruritus, tenderness, and pain, with high recurrence rates post-treatment.
  • Effective keloid treatment and prevention remain challenging, impacting patients psychologically and economically.

Approach:

  • Investigating novel biological and antineoplastic agents for keloid treatment and prevention.
  • Evaluating off-label and experimental therapies including interferon alpha (IFN-α), imiquimod, and transforming growth factor beta1 (TGF-β1).

Key Points:

  • Interferon alpha-2b demonstrated an 18% recurrence rate in postsurgical keloids.
  • Imiquimod 5% reduced recurrence rates to 37.5% at 6 months and 0% at 12 months for postshaved keloids.
  • TGF-β1 oligonucleotides and neutralizing antibodies show potential for scar inhibition in vitro and in animal models.

Conclusions:

  • Emerging therapies offer new avenues for managing keloids and hypertrophic scars.
  • Novel agents show promise in preventing recurrence of postexcision keloid lesions.