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Related Concept Videos

Golgi Matrix Proteins01:12

Golgi Matrix Proteins

1.7K
Golgi matrix proteins are a group of highly dynamic proteins that maintain the stacked structure of Golgi. These proteins adapt to rapid morphological changes of the Golgi during the cell cycle. During cell division, mild proteolysis removes these connections resulting in Golgi unstacking. In The daughter cells, these proteins help reassemble the unstacked Golgi.
One of the first identified Golgi matrix proteins was GM130, a rod-like protein located in the cis-Golgi. Subsequently, many Golgi...
1.7K
Golgi Apparatus01:09

Golgi Apparatus

16.1K
Properly folded and assembled proteins are selectively packaged into vesicles that exit the ER. Motor proteins transport these vesicles to the Golgi apparatus for adding modifications that make these proteins functional at their destination.
The Golgi apparatus is a eukaryotic organelle that has a distinctive ribbon-like appearance. It is a primary sorting and dispatch station for cargo arriving from the ER. Newly arriving vesicles enter the cis face of the Golgi, closest to the ER, and are...
16.1K
Golgi Apparatus01:49

Golgi Apparatus

76.1K
As they leave the Endoplasmic Reticulum (ER), properly folded and assembled proteins are selectively packaged into vesicles. These vesicles are transported by microtubule-based motor proteins and fuse together to form vesicular tubular clusters, subsequently arriving at the Golgi apparatus, a eukaryotic endomembrane organelle that often has a distinctive ribbon-like appearance.
76.1K
Golgi Apparatus01:09

Golgi Apparatus

4.7K
4.7K
Transport Across the Golgi01:26

Transport Across the Golgi

5.2K
While it is unclear how molecules move between adjacent Golgi cisternae, it is apparent that the molecules move from cis- cisterna, the entry face, to the trans- cisterna, the exit face. Experiments initially suggested vesicles that bud from one cisterna and fuse with the next cisterna to transport proteins between the cisternae. This vesicular transport model describes the Golgi apparatus as a relatively static structure with a unique enzyme composition in each cisterna. Molecules are...
5.2K
Vesicular Tubular Clusters01:45

Vesicular Tubular Clusters

2.4K
After budding out from the ER membrane, some COPII vesicles lose their coat and fuse with one another to form larger vesicles and interconnected tubules called vesicular tubular clusters or VTCs. These clusters constitute a compartment at the ER-Golgi interface known as ERGIC (Endoplasmic Reticulum Golgi Intermediate Compartment). The ERGIC is a mobile membrane-bound cargo transport system that sorts proteins secreted from ER and delivers them to the Golgi.
With the help of motor proteins such...
2.4K

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Related Experiment Video

Updated: May 3, 2026

Quantitative Localization of a Golgi Protein by Imaging Its Center of Fluorescence Mass
13:08

Quantitative Localization of a Golgi Protein by Imaging Its Center of Fluorescence Mass

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10.4K

Golgi Feels Its Own Wound.

Charbel Darido1, Stephen M Jane2

  • 1Alfred Hospital , Prahran, Australia .

Advances in Wound Care
|February 15, 2014
PubMed
Summary

The Golgi apparatus is crucial for cell migration and wound repair. Its proper positioning near the cell center is essential for directed secretion and maintaining cell polarity during healing.

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • The Golgi apparatus plays a vital role in protein processing, sorting, and transport, including secretion and cellular relocation.
  • Polarized secretion facilitated by Golgi reorientation is fundamental to cell motility and wound healing.

Approach:

  • Investigated the impact of Golgi positioning disruption on cellular polarity and directional migration during wound repair.
  • Utilized depletion of Golgin-160 or GMAP210 to fragment and disperse the Golgi apparatus without affecting secretion kinetics.

Key Points:

  • Perturbing Golgi positioning severely impaired directional secretion, cell polarization, and migration in response to wounding.
  • Peri-centrosomal Golgi positioning is required for cell polarity initiation and maintenance during wound healing.

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Wide-Field, Real-Time Imaging of Local and Systemic Wound Signals in Arabidopsis

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Related Experiment Videos

Last Updated: May 3, 2026

Quantitative Localization of a Golgi Protein by Imaging Its Center of Fluorescence Mass
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An Injury Paradigm to Investigate Central Nervous System Repair in Drosophila
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  • Golgi's directed secretion is dependent on its position to sustain the polarized state essential for cell migration.

    • Conclusions:

    • Golgi peri-centrosomal positioning is critical for establishing cellular polarity in response to external stimuli, a key aspect of wound repair.
    • Further research into Golgi function in motility may lead to clinical applications for skin disorder treatments.