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An Introduction to Functional Genomics and Systems Biology
Evelien M Bunnik1, Karine G Le Roch1
1Department of Cell Biology and Neuroscience, University of California , Riverside, California.
Advances in Wound Care
|February 15, 2014
Summary
High-throughput technologies enable genome-wide analysis of DNA and proteins, revolutionizing cell biology research. This functional genomics approach provides a comprehensive understanding of biological functions in health and disease.
Area of Science:
- Genomics
- Proteomics
- Systems Biology
Background:
- Cellular research has shifted from single genes/proteins to whole genomes/proteomes.
- High-throughput technologies have dramatically advanced cellular analysis capabilities.
Purpose of the Study:
- To summarize functional genomics technologies and concepts.
- To highlight advancements in DNA and protein analysis.
Main Methods:
- Microarray technology
- Next-generation sequencing
- Mass spectrometry
Main Results:
- Genome-wide analysis of DNA mutations, histone modifications, methylation, chromatin structure, transcription, and translation.
- Global profiling of protein levels, interactions, post-translational modifications, and metabolites.
Conclusions:
- Integrating multi-omics data provides a holistic view of cellular processes.
- This approach enhances understanding of organismal biology in health and disease.
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