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Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...
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Updated: May 3, 2026

A Web Tool for Generating High Quality Machine-readable Biological Pathways
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A Gateway between Omics Data and Systems Biology.

Fabian V Filipp1

  • 1Systems Biology and Cancer Metabolism, Program for Quantitative and Systems Biology, University of California Merced, 5200 North Lake Road, Merced, CA 95343, USA.

Journal of Metabolomics and Systems Biology
|February 15, 2014
PubMed
Summary
This summary is machine-generated.

Metabolomics reveals cellular chemistry, linking biological events to small molecules. Understanding these metabolites is crucial for interpreting physiological systems within systems biology.

Keywords:
BiomarkerFingerprintingFluxomicsGenomicsIntegrativeMetabolomicsModelMultiplexNetworksOmicsPersonalized medicineProfilingProteomicsSystemsTranscriptomics

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Area of Science:

  • Biochemistry
  • Systems Biology
  • Metabolomics

Background:

  • Metabolomics provides a snapshot of cellular chemistry.
  • This cellular chemistry reflects underlying genetic, transcriptional, and enzymatic activities.
  • Interpreting these molecular events requires understanding the role of small molecules.

Purpose of the Study:

  • To highlight the necessity of mechanistic interpretation for metabolites.
  • To emphasize the integration of metabolomics with systems biology.

Main Methods:

  • Utilizing metabolomics to capture cellular small molecules.
  • Applying mechanistic interpretation to understand metabolite function.
  • Integrating omics data with systems biology approaches.

Main Results:

  • Metabolomics directly reflects cellular biochemical processes.
  • Mechanistic interpretation is essential for contextualizing metabolite data.
  • A strong link exists between omics technologies and systems biology.

Conclusions:

  • Metabolomics offers a direct view of cellular biochemical states.
  • Understanding metabolites as substrates, intermediates, or products is key.
  • The synergy between omics and systems biology is vital for biological interpretation.