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[Preparation of Sodium Aescinat micro-emulsion for injection]
Objective:
To prepare and optimize the conditions of Sodium Aescinat micro-emulsion for injection.
Methods:
Sodium Aescinat O/W micro-emulsion (soybean phospholipids + HS15/glycerin/medium chain triglycerides/water) was formulated guided by the pseudo-titration ternary phase diagram.
Results:
Stable Sodium Aescinat micro-emulsion was obtained with medium chain triglycerides as oil, soybean phospholipids + HS15 (1:2) as emulsifier, glycerin as co-emulsifier, and a ratio of emulsifier and co-emulsifier (Km) between 2.00-3.75.
Conclusion:
Stable Sodium Aescinat micro-emulsion can be prepared with conditions described in this study.
