Related Experiment Video
Updated: May 3, 2026
09:45
Radiosensitivity of Cancer Stem Cells in Lung Cancer Cell Lines
Published on: August 21, 2019
6.7K
Cancer stem cells and radioresistance
1Department of Molecular Carcinogenesis, the University of Texas M.D Anderson Cancer Center , Smithville, Texas , USA.
International Journal of Radiation Biology
|February 18, 2014
Summary
Cancer stem cells (CSCs) contribute to tumor recurrence and radiation resistance. Targeting CSCs may improve cancer treatment efficacy, particularly in breast cancer and glioblastoma multiforme (GBM).
Area of Science:
- Oncology
- Cancer Biology
- Radiotherapy Research
Background:
- Radiation therapy is a cornerstone of cancer treatment.
- Tumor recurrence and resistance remain significant challenges.
- Cancer stem cells (CSCs) are implicated in radioresistance.
Purpose of the Study:
- To review CSC-specific mechanisms conferring radiation resistance.
- To explore CSCs as potential therapeutic targets.
Main Methods:
- Literature review focusing on CSCs and radioresistance.
- Analysis of CSC-intrinsic and extrinsic factors.
- Examination of adaptive responses in CSCs.
Main Results:
- CSCs possess inherent mechanisms contributing to radiation resistance.
- Both intrinsic and extrinsic factors influence CSC radioresistance.
- Irradiation and microenvironmental changes induce adaptive responses in CSCs.
Conclusions:
- CSCs play a critical role in treatment failure.
- Targeting CSCs is a promising strategy to enhance radiotherapy.
- Further research into CSC-mediated radioresistance is warranted for breast cancer and GBM.
Keywords:
Cancer stem cellshypoxiamicroenvironmentplasticityradiation therapyradioresistanceradiosensitivityMore Related Videos
Related Concept Videos
02:40Cancer Stem Cells and Tumor Maintenance
4.3K
Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
4.3K
02:40Cancer Stem Cells and Tumor Maintenance
2.0K
2.0K
02:56Treatment Resistant Cancers
2.6K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
2.6K
02:53Adaptive Mechanisms in Cancer Cells
5.7K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.7K
02:53Adaptive Mechanisms in Cancer Cells
3.8K
3.8K
01:18Distinctive Features of Adult Stem Cells vs Cancer Stem Cells
3.8K
A stem cell is an unspecialized cell that can divide without limit as needed and can, under specific conditions, differentiate into specialized cells.
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
Adult stem cells
Adult stem cells are tissue-specific; hence, they divide to develop the tissue from which they originate. One type of adult stem cell is the epithelial stem cell, which gives rise to the keratinocytes in the multiple layers of epithelial cells in the epidermis of the skin. Adult bone marrow has three distinct types of stem cells:...
3.8K