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Using animal models to study post-partum psychiatric disorders.

C V Perani1, D A Slattery

  • 1Department of Behavioural and Molecular Neurobiology, University of Regensburg, Regensburg, Germany.

British Journal of Pharmacology
|February 18, 2014
PubMed
Summary

The post-partum period involves significant maternal changes, but some mothers risk psychiatric disorders like anxiety and depression. Animal models are crucial for understanding the causes of these debilitating conditions.

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Area of Science:

  • Neuroscience
  • Psychiatry
  • Maternal Health

Background:

  • The post-partum period is characterized by significant maternal physiological and psychological adaptations.
  • While often associated with calmness, this period poses a risk for psychiatric disorders, including post-partum anxiety and depression.
  • These disorders negatively impact maternal well-being and infant long-term health.

Purpose of the Study:

  • To review normal peripartum adaptations.
  • To describe post-partum mood and anxiety disorders, including risk factors, prevalence, and symptoms.
  • To discuss animal models used to study the etiology of these disorders.

Main Methods:

  • Literature review of peripartum adaptations and post-partum psychiatric disorders.
  • Analysis of existing animal models for studying post-partum mood and anxiety disorders.
  • Synthesis of findings from animal models regarding the underlying mechanisms.

Main Results:

  • Peripartum adaptations are well-documented, as are risk factors and symptoms of post-partum psychiatric disorders.
  • Animal models have been developed to investigate the neurobiological underpinnings of these conditions.
  • Current research indicates the feasibility of using animal models to study complex post-partum psychiatric disorders.

Conclusions:

  • Understanding the etiology of post-partum psychiatric disorders is crucial for effective intervention.
  • Animal models offer a valuable tool for elucidating the mechanisms behind these conditions.
  • Further research using animal models is needed to enhance knowledge and develop better treatments.