Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Substance-P-like levels in inflammatory exudates.

M Tissot¹, P Pradelles, J P Giroud

¹Département de Pharmacologie, CNRS UA 595, CHU Cochin-Port Royal, Paris, France.

|February 1, 1988

Summary

Substance P (SP)-like material is released during rat pleurisy induced by calcium pyrophosphate or carrageenan. This suggests SP-like substances play a role in the inflammatory response and pain signaling.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

[Interest of several pharmaceutical activities to secure the care pathway of elderly patients?]

Annales pharmaceutiques francaises·2019

Same author

Clinical presentation of endometriosis identified at interval laparoscopic tubal sterilization: Prospective series of 465 cases.

Journal of gynecology obstetrics and human reproduction·2017

Same author

Differential morphological and functional features of fibroblasts explanted from solar lentigo.

The British journal of dermatology·2017

Same author

Risk factors of postoperative vomiting in children receiving continuous intravenous morphine.

Minerva anestesiologica·2011

Same author

Regional distribution of met-enkephalin within the amygdaloid complex and bed nucleus of the stria terminals.

Neuroscience letters·2009

Same author

In Vivo Nitric Oxide Synthase Inhibitors Can Be Deprived of This Activity: Unexpected Influence of the Tetrachloroplatinate(II) Counteranion. Crystal Structures of Bis(S-Methyl-Isothiouronium)-N,N'-Bis(3-Guanidinopropyl)Piperazinium and Hexamidinium Tetrachloroplatinates(II) Salts.

Metal-based drugs·2008

Area of Science:

Immunology
Neuroscience
Pharmacology

Background:

Substance P (SP) is a neuropeptide involved in pain and inflammation.
The role of SP in pleural inflammation is not fully understood.

Purpose of the Study:

To investigate the release of SP-like immunoreactivity in rat pleural exudates.
To explore the potential involvement of SP in inflammatory processes.

Main Methods:

Induction of pleurisy in rats using intrapleural injections of calcium pyrophosphate (CaPP) or carrageenan.
Quantification of SP-like levels in pleural exudates using enzyme immunoassay.

Main Results:

SP-like levels significantly increased in exudates induced by both CaPP and carrageenan.
Peak SP-like levels were observed at different time points depending on the irritant.
A correlation between exudate volume and SP-like amounts was noted with carrageenan.

Conclusions:

A detectable release of SP-like material occurs in pleural exudates.
SP-like substances may contribute to inflammatory responses, vascular changes, or nociception in the pleura.

Related Experiment Videos