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Beta-subunit of baboon chorionic gonadotropin. Continuous flow Fmoc-polyamide synthesis of the C-terminal 37-peptide
C R Wu1, J D Wade, G W Tregear
1Howard Florey Institute of Experimental Physiology and Medicine, University of Melbourne, Parkville, Victoria, Australia.
International Journal of Peptide and Protein Research
|January 1, 1988
Abstract:
The synthesis of a 37-peptide fragment derived from the carboxyl terminal of the beta-subunit of baboon chorionic gonadotropin has been accomplished by the continuous flow Fmoc-polyamide solid phase method. The use of N alpha-fluorenylmethoxy-carbonyl-glutamine with its sidechain protected by the 4,4'-dimethoxybenzhydryl group enabled successful incorporation of this residue onto a hydroxymethyl linkage agent without apparent side reaction.