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The Concise Guide to PHARMACOLOGY 2013/14: overview.

Stephen P H Alexander1, Helen E Benson, Elena Faccenda

  • 1School of Life Sciences, University of Nottingham Medical School, Nottingham, NG7 2UH, UK.

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|February 18, 2014
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This summary is machine-generated.

The Concise Guide to Pharmacology 2013/14 offers a summary of over 2000 human drug targets and their pharmacology. This guide, linked to an open-access knowledgebase, provides essential information for researchers.

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Area of Science:

  • Pharmacology
  • Drug Discovery
  • Biomedical Science

Background:

  • The International Union of Basic and Clinical Pharmacology (IUPHAR) curates drug target information.
  • Previous guides and databases (IUPHAR-DB, GRAC) contained detailed, yet fragmented, data.
  • A need existed for a consolidated, accessible overview of human drug targets.

Purpose of the Study:

  • To provide a concise overview of key properties for over 2000 human drug targets.
  • To link to an open-access knowledgebase for detailed pharmacology and ligand information.
  • To establish an official IUPHAR classification and nomenclature for human drug targets.

Main Methods:

  • Compilation of data on major pharmacological targets, categorized into seven areas.
  • Presentation of nomenclature guidance and summary information on pharmacological tools.
  • Inclusion of key references and suggestions for further reading.

Main Results:

  • A comprehensive guide detailing over 2000 human drug targets and their pharmacology.
  • Integration of information from IUPHAR-DB and GRAC into a single resource.
  • A new landscape format with comparative tables for related targets.

Conclusions:

  • The Concise Guide to Pharmacology 2013/14 serves as a valuable, citable resource for drug target information.
  • The linked open-access knowledgebase (www.guidetopharmacology.org) provides continuously updated, detailed data.
  • This guide consolidates and standardizes crucial information for the pharmacology community.