The Concise Guide to PHARMACOLOGY 2013/14: overview

Area of Science:

• Pharmacology
• Drug Discovery
• Biomedical Science

Background:

• The International Union of Basic and Clinical Pharmacology (IUPHAR) curates drug target information.
• Previous guides and databases (IUPHAR-DB, GRAC) contained detailed, yet fragmented, data.
• A need existed for a consolidated, accessible overview of human drug targets.

Purpose of the Study:

• To provide a concise overview of key properties for over 2000 human drug targets.
• To link to an open-access knowledgebase for detailed pharmacology and ligand information.
• To establish an official IUPHAR classification and nomenclature for human drug targets.

Main Methods:

• Compilation of data on major pharmacological targets, categorized into seven areas.
• Presentation of nomenclature guidance and summary information on pharmacological tools.
• Inclusion of key references and suggestions for further reading.

Main Results:

• A comprehensive guide detailing over 2000 human drug targets and their pharmacology.
• Integration of information from IUPHAR-DB and GRAC into a single resource.
• A new landscape format with comparative tables for related targets.

Conclusions:

• The Concise Guide to Pharmacology 2013/14 serves as a valuable, citable resource for drug target information.
• The linked open-access knowledgebase (www.guidetopharmacology.org) provides continuously updated, detailed data.
• This guide consolidates and standardizes crucial information for the pharmacology community.