Intestinal permeability measurements: general aspects and possible pitfalls
Tatiana Fiche Salles Teixeira1, Ana Paula Boroni Moreira1, Nilian Carla Silva Souza2
1Department of Nutrition and Health. Federal University of Viçosa. Brazil.. tatifichee@hotmail.com.
Nutricion Hospitalaria
|February 18, 2014
Summary
Intestinal barrier dysfunction, often due to tight junction issues, increases gut permeability. Intestinal permeability tests, using probes like lactulose and mannitol, help assess disease severity and guide treatment.
Area of Science:
- Gastroenterology
- Physiology
- Pathology
Background:
- Gut barrier dysfunction is linked to various intestinal and extra-intestinal diseases.
- Intestinal permeability tests are valuable for assessing disease severity and monitoring therapeutic responses.
Purpose of the Study:
- To review factors contributing to increased intestinal permeability.
- To identify associated clinical conditions across different age groups.
- To discuss methodological considerations for intestinal permeability testing.
Main Methods:
- Review of literature on intestinal permeability.
- Analysis of factors influencing gut barrier function.
- Discussion of clinical applications and methodological challenges.
Main Results:
- Abnormal tight junction regulation is a primary cause of altered intestinal barrier function.
- Impaired barrier function leads to increased permeation of probes like lactulose and mannitol.
- Intestinal permeability tests are simple and safe for evaluating barrier dysfunction.
Conclusions:
- Intestinal permeability tests can expand knowledge on diseases involving barrier dysfunction.
- Numerous factors can influence test results, requiring careful consideration.
- Standardizing test methodologies and exploring additional physiological markers are crucial for reliable evidence.
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