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Published on: September 15, 2018
Cardiovascular microRNAs: as modulators and diagnostic biomarkers of diabetic heart disease
Shruti Rawal, Patrick Manning, Rajesh Katare1
1Department of Physiology, HeartOtago, Otago School of Medical Sciences, University of Otago, Dunedin, New Zealand. rajesh.katare@otago.ac.nz.
Insights
Diabetic heart disease (DHD) is a major complication of diabetes, often undetected early. This review explores microRNAs (miRs) as potential biomarkers and therapeutic targets for DHD.
Area of Science:
- Cardiology
- Endocrinology
- Molecular Biology
Background:
- Diabetic heart disease (DHD) causes significant morbidity and mortality in diabetic patients, often presenting asymptomatically until advanced stages.
- Early detection and treatment of DHD are hindered by its asymptomatic nature in early development.
- Understanding DHD pathophysiology is crucial for developing targeted therapies and improving diagnostic strategies for diabetes-associated cardiovascular complications.
Purpose of the Study:
- To review the mechanisms of cardiovascular microRNAs (miRs) in relation to cardiovascular diseases.
- To discuss the potential involvement of miRs in the pathophysiology of DHD.
- To explore the utility of miRs as diagnostic biomarkers for DHD.
Main Methods:
- Literature review focusing on cardiovascular microRNAs.
- Analysis of miR regulatory roles in cardiac gene expression and cellular processes.
- Evaluation of circulating miRs as potential biomarkers for cardiovascular disease.
Main Results:
- MicroRNAs (miRs) are key regulators of cardiac gene expression and cellular processes.
- miRs are released into circulation during disease states, serving as potential diagnostic biomarkers.
- The specific roles of miRs in DHD pathophysiology and as diagnostic markers remain largely unexplored.
Conclusions:
- Cardiovascular miRs hold potential as modulators and diagnostic biomarkers in diabetic heart disease.
- Further research into miRs could lead to early diagnosis and novel therapeutic strategies for DHD.
- Exploring miRs' involvement in DHD is essential for advancing cardiovascular care in diabetic patients.
Abstract:
Diabetic heart disease (DHD) is the leading cause of morbidity and mortality among the people with diabetes, with approximately 80% of the deaths in diabetics are due to cardiovascular complications. Importantly, heart disease in the diabetics develop at a much earlier stage, although remaining asymptomatic till the later stage of the disease, thereby restricting its early detection and active therapeutic management. Thus, a better understanding of the modulators involved in the pathophysiology of DHD is necessary for the early diagnosis and development of novel therapeutic implications for diabetes-associated cardiovascular complications. microRNAs (miRs) have recently been evolved as key players in the various cardiovascular events through the regulation of cardiac gene expression. Besides their credible involvement in controlling the cellular processes, they are also released in to the circulation in disease states where they serve as potential diagnostic biomarkers for cardiovascular disease. However, their potential role in DHD as modulators as well as diagnostic biomarkers is largely unexplored. In this review, we describe the putative mechanisms of the selected cardiovascular miRs in relation to cardiovascular diseases and discuss their possible involvement in the pathophysiology and early diagnosis of DHD.
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