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Functionality of chitin as a direct compression excipient: an acetaminophen comparative study.

John Rojas1, Yhors Ciro1, Luisa Correa1

  • 1Department of Pharmacy, School of Pharmaceutical Chemistry, The University of Antioquia, Medellin, Colombia.

Carbohydrate Polymers
|February 18, 2014
PubMed
Summary

Chitin from shrimp exoskeletons shows promise as a direct compression excipient. It offers superior functionality and compactibility compared to common tablet ingredients like lactose and starch.

Keywords:
Acetaminophen excipientsChitinChitin excipient physical propertiesDirect compression tabletingTableting properties

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Area of Science:

  • Pharmaceutical Sciences
  • Materials Science

Background:

  • Tableting excipients are crucial for drug formulation.
  • Chitin, a biopolymer from crustacean shells, has potential pharmaceutical applications.

Purpose of the Study:

  • To evaluate the particle and tableting properties of chitin.
  • To compare chitin's functionality against common pharmaceutical excipients.

Main Methods:

  • Extraction and characterization of chitin from shrimp exoskeletons.
  • Comparative analysis of chitin's compactibility, dilution potential, and sensitivity to compaction speed and lubricants.
  • Acetaminophen loading capacity assessment.

Main Results:

  • Chitin demonstrated superior functionality and compactibility over pregelatinized starch, calcium diphosphate, and lactose monohydrate.
  • Chitin exhibited a favorable combination of plastic and brittle deformation, reducing sensitivity to compaction speed.
  • Chitin showed lower sensitivity to magnesium stearate and better acetaminophen loading capacity than other tested excipients.

Conclusions:

  • Chitin possesses advantageous tableting properties, outperforming several conventional excipients.
  • Chitin's characteristics suggest its suitability as a direct compression excipient in tablet formulations.