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Updated: May 3, 2026

A Thrombotic Stroke Model Based On Transient Cerebral Hypoxia-ischemia
Published on: August 18, 2015
Intravenous thrombolysis is unsafe in stroke due to infective endocarditis
W J Brownlee1, N E Anderson, P A Barber
1Department of Neurology, Auckland City Hospital, Auckland, New Zealand.
Abstract:
Embolic stroke is the most common neurological complication of infective endocarditis and a major source of morbidity and mortality. Septic embolism is considered a contraindication to intravenous thrombolysis in patients with ischaemic stroke because of concerns over an increased risk of intracranial haemorrhage. We describe a patient with occult endocarditis who was treated with thrombolysis for acute stroke and review other cases reported in the literature.
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