Related Experiment Video

Updated: May 3, 2026

Operant Procedures for Assessing Behavioral Flexibility in Rats
08:30

Operant Procedures for Assessing Behavioral Flexibility in Rats

Published on: February 15, 2015

20.9K

A trial evaluating gradual- or immediate-switch strategies from risperidone, olanzapine, or aripiprazole to

Peter J Weiden1, Leslie Citrome2, Gus Alva3

  • 1University of Illinois at Chicago, UIC Medical Center, 912 South Wood Street, MC 913, Chicago, IL 60612, USA.

Schizophrenia Research
|February 18, 2014
PubMed

Insights

Switching to iloperidone for schizophrenia treatment showed similar efficacy and safety whether done gradually or immediately. Both methods resulted in comparable outcomes and adverse events at 12 weeks.

Area of Science:

  • Psychiatry
  • Pharmacology
  • Clinical Trials

Background:

  • Schizophrenia treatment often involves switching antipsychotics due to inadequate efficacy or tolerability.
  • Iloperidone is an atypical antipsychotic used for schizophrenia management.
  • Optimizing the switching strategy between antipsychotics is crucial for patient outcomes.

Purpose of the Study:

  • To compare the efficacy and safety of a gradual versus immediate switch to iloperidone in adults with schizophrenia.
  • To evaluate outcomes based on the Integrated Clinical Global Impression of Change (I-CGI-C) at 12 weeks.

Main Methods:

  • A 12-week, randomized, open-label trial involving 500 adults with schizophrenia.
  • Patients inadequately treated with risperidone, olanzapine, or aripiprazole were randomized to switch to iloperidone either gradually or immediately.
  • Iloperidone dosing was initiated and adjusted over the trial period.

Main Results:

  • No clinically significant differences in I-CGI-C scores were observed between the gradual and immediate switch groups at 12 weeks.
  • Adverse event profiles were similar across both switching methods and across different prior antipsychotic agents.
  • Common adverse events included dizziness, dry mouth, somnolence, and weight increase.

Conclusions:

  • Both gradual and immediate switching strategies to iloperidone are effective and well-tolerated for patients with schizophrenia.
  • The method of switching does not appear to significantly impact overall efficacy or safety outcomes.
  • Iloperidone offers a viable treatment option with comparable results regardless of the switching approach.
Keywords:
Clinical improvementIloperidoneSafetySchizophreniaSwitch strategyTolerability

More Related Videos

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats09:12

Three Laboratory Procedures for Assessing Different Manifestations of Impulsivity in Rats

Published on: March 17, 2019

9.6K
Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis05:52

Handwriting Analysis Indicates Spontaneous Dyskinesias in Neuroleptic Naïve Adolescents at High Risk for Psychosis

Published on: November 21, 2013

13.6K

Related Concept Videos

Psychosis: Goals of Pharmacotherapy01:26

Psychosis: Goals of Pharmacotherapy

Antipsychotic drugs are a crucial treatment method for acute and chronic psychoses, bipolar illness, and behavioral disorders. The selection of these drugs depends on several factors, including the state of the disease, clinical judgment, possible drug interactions, and the patient's sensitivity to adverse effects. In immediate scenarios, such as delirium and dementia, short-term treatment with low doses of high-potency typical or atypical agents can effectively manage symptom exacerbation.
706
Psychosis and Antipsychotic Drugs: Overview01:28

Psychosis and Antipsychotic Drugs: Overview

The term "psychosis" refers to a spectrum of mental disorders characterized by abnormal thoughts, perceptions, and behaviors. It can manifest as mood disorders, dementia, delirium with psychotic features, substance-induced psychosis with psychotic features, brief psychotic disorder, delusional disorder, schizoaffective disorder, and schizophrenia. Among all these disorders, schizophrenia is the most common psychotic disorder, affecting 1% of the worldwide population. Psychotic...
1.2K
Antipsychotic Drugs: Typical and Atypical Agents01:21

Antipsychotic Drugs: Typical and Atypical Agents

Antipsychotic drugs are classified into first-generation (typical) drugs including phenothiazines; and second-generation (atypical) drugs. Chlorpromazine hydrochloride (Thorazine), a phenothiazine derivative, broadly impacts the central, autonomic, and endocrine systems. This drug, along with typical agents like haloperidol (Haldol), primarily works by antagonizing D2 receptors, thus reducing dopaminergic neurotransmission. However, typical antipsychotics can cause side effects such as sedation...
1.3K
Drug Therapy01:28

Drug Therapy

The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
449
Drug Accumulation During Multiple Dosing: Intermittent IV Infusions01:24

Drug Accumulation During Multiple Dosing: Intermittent IV Infusions

Intermittent intravenous (IV) infusion is a method of drug administration where medications are delivered over short infusion periods followed by intervals of no drug delivery. This approach helps to prevent sustained high drug concentrations in the bloodstream, reducing the risk of adverse effects associated with prolonged exposure. Unlike continuous infusion, steady-state concentrations may not be achieved during a single dosing cycle but can be reached through repeated...
423
IV Infusion to Oral Dosing: Conversion Methods01:28

IV Infusion to Oral Dosing: Conversion Methods

The development of extended-release formulations has facilitated the transition from intravenous to oral medication, offering a more convenient and patient-friendly approach to drug administration. This transition, however, requires careful management to ensure that therapeutic drug levels are maintained, preserving efficacy and avoiding adverse effects. Understanding pharmacokinetic principles and dosage calculations is critical during this process.Pharmacokinetics of the...
212