Jove
Visualize
Contact Us

Related Experiment Videos

Cybernetic origins of replication.

D P Bloch1

  • 1Botany Department, University of Texas, Austin 78713.

Origins of Life and Evolution of the Biosphere : the Journal of the International Society for the Study of the Origin of Life
|January 1, 1988
PubMed
Summary

This study outlines an evolutionary pathway to replication, detailing phases from RNA segment replication to DNA. It suggests selection shifts from external factors to the replicator itself, enabling Darwinian evolution.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

CHANGES IN NUCLEAR HISTONES DURING FERTILIZATION, AND EARLY EMBRYONIC DEVELOPMENT IN THE PULMONATE SNAIL, Helix aspersa.

The Journal of biophysical and biochemical cytology·2009
Same author

EVIDENCE For THE CYTOPLASMIC SYNTHESIS OF NUCLEAR HISTONE DURING SPERMIOGENESIS IN THE GRASSHOPPER CHORTOPHAGA VIRIDIFASCIATA (DE GEER).

The Journal of cell biology·2009
Same author

tRNA-rRNA sequence matches from inter- and intraspecies comparisons suggest common origins for the two RNAs.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas·1989
Same author

Demonstrating evolutionary relationships between macromolecular sequences through mutual relationships with a third sequence.

Zeitschrift fur Naturforschung. C, Journal of biosciences·1988
Same author

Evolution of E. coli tRNA(Trp).

Origins of life and evolution of the biosphere : the journal of the International Society for the Study of the Origin of Life·1988
Same author

Evolution of E. coli tRNA(Ile): evidence of derivation from other tRNAs.

Zeitschrift fur Naturforschung. C, Journal of biosciences·1987
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Area of Science:

  • Origin of Life Studies
  • Molecular Evolution
  • Biochemistry

Background:

  • Early molecular evolution likely involved self-replicating RNA segments.
  • Tandem repeats in ancestral molecules may have preceded modern structural RNAs.
  • Sequence similarities in transfer and ribosomal RNAs suggest conserved ancestral features.

Purpose of the Study:

  • To resolve the evolutionary progression toward molecular replication into distinct phases.
  • To investigate the role of selection's source and focus in this progression.
  • To establish a framework for understanding the emergence and potential transcendence of Darwinian evolution.

Main Methods:

  • Analysis of molecular sequence data to identify ancestral repeat patterns.
  • Conceptual modeling of evolutionary phases and selection dynamics.
  • Examination of conserved sequence periodicities in structural RNAs.

Main Results:

  • Identified four phases of replication: RNA segments, single-stranded molecules, duplexes, and DNA.
  • Evidence suggests early molecules possessed tandem repeats, with relics in current RNAs.
  • Selection's source and focus shift internally, leading to self-replication and Darwinian evolution.

Conclusions:

  • Catalytic specificity precedes natural selection in molecular evolution.
  • Internalized selection, where source and focus converge on the replicator, is key to Darwinian evolution.
  • Control mechanisms offer a framework for understanding transitions into and out of Darwinian evolution.

Related Experiment Videos