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Successful salvage therapy with micafungin for Candida empyema thoracis

Pai-Yang Lin1, Shio-Shin Jean2, Tsong-Yih Ou2

  • 1Division of Chest Medicine, Department of Internal Medicine, Wan Fang Medical Center, Taipei Medical University, Taipei, Taiwan.

Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi
|February 18, 2014
PubMed
Abstract

No abstract available in PubMed .

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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to...
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