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Related Concept Videos

Selectins01:25

Selectins

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Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain,...
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Adaptive Mechanisms in Cancer Cells02:53

Adaptive Mechanisms in Cancer Cells

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Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
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Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
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Receptor Downregulation in MVBs01:15

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Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that  lead to cell proliferation, migration, and differentiation. Overexpression of EGFR  stimulates cells to proliferate. Excessive  EGFR...
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Activation of Integrins01:15

Activation of Integrins

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Integrins bind ligands and transmit information from outside the cell to inside or vice-versa through an "outside-in signaling" or "inside-out signaling."
In "outside-in signaling," external factors in the extracellular space bind to exposed ligand binding sites on integrins. This causes the inactive protein to undergo a conformational change to become active. Integrins are often clustered on the cell membrane. Repetitive and regularly spaced ligand binding...
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Mitogens and the Cell Cycle02:38

Mitogens and the Cell Cycle

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Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...
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Three-Dimensional 3D Tumor Spheroid Invasion Assay
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Galectin-3 in cancer.

Lin Song1, Jian-wu Tang1, Lawrence Owusu2

  • 1The Key Laboratory of Tumor Metastasis in Liaoning Province, Department of Pathology, Dalian Medical University, 9 West, Lvshun Southern Road, Dalian 116044, China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|February 18, 2014
PubMed
Summary
This summary is machine-generated.

Galectin-3 (Gal-3) is crucial in cancer development, affecting cell processes like migration and metastasis. This review highlights Gal-3 as a promising biomarker for cancer diagnosis and treatment.

Keywords:
CancerExpressionGalectin-3 (Gal-3)LocationMechanism

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Oncology

Background:

  • Galectin-3 (Gal-3) is implicated in cellular functions including proliferation, adhesion, differentiation, angiogenesis, and apoptosis.
  • Evidence suggests Gal-3's involvement in tumor cell transformation, migration, invasion, and metastasis.

Purpose of the Study:

  • To review the associations between Gal-3 expression and localization and its mechanisms in tumorigenesis.
  • To explore Gal-3's potential as a biomarker in various cancers.

Main Methods:

  • Literature review of studies on Galectin-3 expression, localization, and function in cancer.
  • Analysis of potential action mechanisms of Gal-3 in tumorigenesis.

Main Results:

  • Gal-3 expression and localization patterns are linked to tumorigenesis across diverse cancers.
  • Gal-3 influences key processes critical for cancer progression.

Conclusions:

  • Galectin-3 is significantly involved in cancer development and progression.
  • Gal-3 shows potential as a novel biomarker for cancer diagnosis, treatment, and prognosis.