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Cardiac biomarkers in heart failure
Michael E Liquori1, Robert H Christenson2, Paul O Collinson3
1University of Maryland School of Medicine, Department of Internal Medicine, 22 S. Greene St, Baltimore, MD 21201, USA.
Clinical Biochemistry
|February 18, 2014
Summary
Blood biomarkers are crucial for managing heart failure, aiding in early diagnosis, prognosis, and treatment. As heart failure prevalence rises globally, these markers will become increasingly vital for patient care.
Area of Science:
- Cardiology
- Biomarker Research
- Clinical Diagnostics
Background:
- Heart failure is a global health concern with increasing prevalence due to aging populations.
- The condition signifies the heart's inability to meet the body's circulatory demands.
- Advancements in cardiac therapies highlight the growing importance of biomarkers in patient management.
Purpose of the Study:
- To review clinical research on blood-based biomarkers for heart failure.
- To focus on currently available biomarkers for clinical measurement.
- To explore current and potential applications in managing heart failure patients.
Main Methods:
- Systematic review of clinical research on heart failure biomarkers.
- Analysis of biomarkers for diagnosis, prognosis, and therapeutic guidance.
- Evaluation of biomarkers based on clinical availability and application.
Main Results:
- Heart failure biomarkers are associated with diverse biologic pathways: inflammation, remodeling, strain, neurohormonal activation, metabolism, and cardiac myocyte injury.
- The review discusses the clinical characteristics and applications of various heart failure biomarkers.
- Specific biomarkers are linked to different pathophysiological processes in heart failure.
Conclusions:
- Heart failure incidence and prevalence are expected to increase with aging populations and improved cardiovascular disease interventions.
- Blood biomarkers will play a progressively significant role in the future management of heart failure.
- Biomarkers are essential for early diagnosis, therapeutic monitoring, and overall patient management in heart failure.
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