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Assessing Therapeutic Angiogenesis in a Murine Model of Hindlimb Ischemia
Published on: June 8, 2019
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Hybrid revascularization procedures in acute limb ischemia
Christos Argyriou1, Efstratios Georgakarakos1, George S Georgiadis1
1Department of Vascular Surgery, "Democritus" Medical School, University Hospital of Alexandroupolis, Alexandroupolis, Greece.
Annals of Vascular Surgery
|February 18, 2014
Summary
Emergent hybrid revascularization effectively treats acute lower limb ischemia, offering durable limb salvage and survival in high-risk patients. This approach shows promising clinical outcomes for limb salvage and survival rates.
Area of Science:
- Vascular Surgery
- Endovascular Interventions
- Acute Limb Ischemia Management
Background:
- Limited evidence exists for hybrid procedures in acute limb ischemia.
- This study evaluates emergent hybrid reconstructions for acute lower limb ischemia.
Purpose of the Study:
- To assess the immediate and midterm clinical outcomes of hybrid revascularization in acute lower limb ischemia.
- To determine the efficacy and safety of this emergent procedure.
Main Methods:
- A cohort of 28 patients with acute lower limb ischemia underwent emergent hybrid revascularization.
- Follow-up was conducted for a median of 6 months, assessing technical success, hemodynamic improvement (Ankle Brachial Pressure Index), patency, limb salvage, and survival rates.
Main Results:
- Technical success was 100%, with a 98% hemodynamic improvement rate.
- Six-month outcomes included 86% overall patency, 92% limb salvage, and 79% survival.
- Perioperative morbidity and mortality rates were 21% and 11%, respectively.
Conclusions:
- Emergent hybrid revascularization is an effective and durable option for limb salvage in high-risk patients with acute lower limb ischemia.
- The procedure offers acceptable mortality and amputation rates.
- Larger studies are recommended to confirm these findings.
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