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Plasma histamine levels in rats treated with trypanocidal diamidines
U Steinmann1, C J Estler, O Dann
1Institute für Pharmakologie und Toxikologie, Universität Erlangen-Nürnberg, BRD.
Pharmacology
|January 1, 1988
Abstract:
The histamine levels in rat plasma treated with various new trypanocidal diamidines and diimidazolines were evaluated by HPLC and fluorometric detection. Equimolar doses (10 mumol/kg) of the new compounds raised the plasma histamine level to a much smaller degree than pentamidine or diminazene.