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Updated: May 3, 2026

Synthesis and Purification of Iodoaziridines Involving Quantitative Selection of the Optimal Stationary Phase for Chromatography
Published on: May 16, 2014
Quantitative analysis of iobitridol in an injectable preparation by 1H NMR spectroscopy
Anna Borioni1, Gianluca Gostoli1, Elena Bossù1
1Istituto Superiore di Sanità, Dipartimento del Farmaco, Rome, Italy.
Abstract:
Nuclear magnetic resonance spectroscopy was used for direct quantitative determination of iobitridol in an injectable formulation. The method was developed on a medium field strength magnet (400MHz) and validation was performed by assessing specificity, accuracy, precision, linearity, stability of samples and robustness. Validation data confirm that the method is highly appropriate for direct quantification of iobitridol in the final formulation. Moreover the method has a good potential for rapid screening analyses due to straightforward experimental setup and lack of any sample pretreatment.
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