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Related Experiment Video

Updated: May 3, 2026

3D Human Myocardial Tissue Generation Using Melt Electrospinning Writing of Polycaprolactone Scaffolds and hiPSC-Derived Cardiac Cells
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Plasma-functionalized electrospun matrix for biograft development and cardiac function stabilization.

A G Guex1, A Frobert2, J Valentin2

  • 1Empa, Swiss Federal Laboratories for Materials Science and Technology, 9000 St. Gallen, Switzerland; Department of Cardiovascular Surgery, University Hospital and University of Bern, 3010 Bern, Switzerland; Graduate School for Cellular and Biomedical Sciences, University of Bern, 3010 Bern, Switzerland.

Acta Biomaterialia
|February 18, 2014
PubMed
Summary
This summary is machine-generated.

Radio-frequency plasma functionalized poly(ɛ-caprolactone) scaffolds support mesenchymal stem cell (MSC) cardiac implantation. MSC-seeded patches stabilized cardiac function after myocardial infarction in rats, unlike acellular patches.

Keywords:
Cardiac tissue engineeringEchocardiography: cell therapyElectrospinningIn vivo functional evaluationPlasma polymerization

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Area of Science:

  • Biomedical Engineering
  • Regenerative Medicine
  • Cardiovascular Research

Background:

  • Myocardial infarction (MI) leads to progressive heart failure, necessitating innovative treatments.
  • Cardiac tissue engineering offers potential for cell delivery to damaged myocardium.
  • Optimizing scaffold properties (architecture, mechanical, chemical, biocompatibility) is crucial for successful cardiac repair.

Purpose of the Study:

  • To evaluate radio-frequency plasma surface functionalized electrospun poly(ɛ-caprolactone) (PCL) fibers as a scaffold for mesenchymal stem cell (MSC) cardiac implantation.
  • To assess the efficacy of MSC-seeded plasma-coated PCL grafts in a rat model of chronic myocardial infarction.

Main Methods:

  • Fabrication of electrospun PCL fibers functionalized via radio-frequency plasma treatment.
  • Seeding of bone-marrow-derived MSCs onto the plasma-coated PCL scaffolds.
  • Implantation of MSC-seeded and acellular PCL patches in a rat model of chronic MI.
  • Assessment of cardiac function using ejection fraction (EF) and fractional shortening (FS) measurements.

Main Results:

  • Plasma-coated PCL fibers provided a suitable matrix for MSC cardiac implantation.
  • MSC-seeded plasma-coated PCL grafts significantly stabilized cardiac function and attenuated cardiac dilatation post-MI.
  • Sham-treated and acellular patch groups showed significant decreases in EF and FS, while the MSC-patch group maintained cardiac function (6% decrease).

Conclusions:

  • Radio-frequency plasma surface functionalization of PCL electrospun fibers creates a viable scaffold for cardiac tissue engineering.
  • MSC-seeded PCL patches demonstrate therapeutic potential in improving cardiac function after myocardial infarction.
  • This approach offers a promising strategy for treating heart failure following MI.