Related Experiment Video
Updated: May 3, 2026

Author Spotlight: Developing a Bedside Protocol for Kidney and Genitourinary Ultrasonography
Published on: June 21, 2024
CT urography for the diagnosis of medullary sponge kidney
Farrukh M Koraishy1, Thuy-Trang T Ngo, Gary M Israel
1Section of Nephrology, Yale University School of Medicine, New Haven, Conn., USA.
Background:
Medullary sponge kidney (MSK) is characterized by malformation of the terminal collecting ducts and is associated with an increased risk of nephrolithiasis, nephrocalcinosis, urinary tract infections, renal acidification defects, and reduced bone density. It has been historically diagnosed with intravenous pyelography (IVP), which is falling out of favor as an imaging modality. CT urography (CTU) performed with multidetector CT (MDCT) has been shown to create images of the renal collecting system with similar detail as IVP; however, its utility in diagnosing MSK has not been defined.
Case Report:
We present the first 15 patients with recurrent symptomatic nephrolithiasis who were evaluated in our renal stone clinic with CTU. Four patients were diagnosed with MSK after visualization of the characteristic radiologic findings.
Discussion:
CTU effectively demonstrates the characteristic radiologic findings of MSK including collecting tubule dilatation, medullary nephrocalcinosis, nephrolithiasis, and medullary cysts. Dose reduction protocols can reduce radiation exposure below that associated with conventional IVP. We propose CTU be considered for the diagnosis of MSK.
Insights
Computed tomography urography (CTU) can diagnose medullary sponge kidney (MSK) by visualizing characteristic radiologic findings. This imaging technique offers a valuable alternative to traditional methods for diagnosing MSK and related complications.
Area of Science:
- Nephrology
- Radiology
- Medical Imaging
Background:
- Medullary sponge kidney (MSK) involves terminal collecting duct malformations, increasing risks of kidney stones, infections, and bone density loss.
- Intravenous pyelography (IVP) was the historical diagnostic standard but is now less favored.
- CT urography (CTU) using multidetector CT (MDCT) offers comparable detail to IVP for renal collecting system imaging.
Observation:
- The study evaluated 15 patients with recurrent kidney stones using CTU.
- Four patients were diagnosed with MSK based on characteristic imaging findings.
- CTU effectively visualized collecting tubule dilatation, medullary nephrocalcinosis, kidney stones, and cysts.
Findings:
- CTU accurately demonstrates key radiologic features of MSK.
- The diagnostic utility of CTU for MSK has now been defined.
- Radiation exposure can be minimized with dose reduction protocols.
Implications:
- CTU is proposed as a diagnostic tool for medullary sponge kidney.
- This imaging modality may replace or supplement traditional methods.
- Further research may explore CTU's role in managing MSK patients.
Related Concept Videos
Imaging Studies V: Intravenous Urography and Retrograde Pyelography
Imaging Studies II: Ultrasonography
Imaging Studies I: Kidney, Ureter, and Bladder Studies
Urologic Endoscopic Procedure: Cystoscopic Examination
Imaging Studies III: Computed Tomography
Imaging Studies VI: Voiding Cystourethrography and Cystography

