Salmonellae PhoPQ regulation of the outer membrane to resist innate immunity
Zachary D Dalebroux1, Samuel I Miller2
1Department of Microbiology, University of Washington, Seattle, WA, United States.
Abstract:
Salmonellae sense host cues to regulate properties important for bacterial survival and replication within host tissues. The PhoPQ two-component regulatory system senses phagosome acidification and cationic antimicrobial peptides (CAMP) to regulate the protein and lipid contents of the bacterial envelope that comprises an inner and outer membrane. PhoPQ-regulated lipid components of the outer membrane include lipopolysaccharides and glycerophospholipids. Envelope proteins regulated by PhoPQ, include: components of virulence associated secretion systems, the flagellar apparatus, membrane transport systems, and proteins that are likely structural components of the outer membrane. PhoPQ alteration of the bacterial surface results in increased bacterial resistance to CAMP and decreased detection by the innate immune system. This review details the molecular complexity of the bacterial cell envelope and highlights the outer membrane lipid bilayer as an environmentally regulated bacterial organelle.
More Related Videos
06:30A Non-Coding Small RNA MicC Contributes to Virulence in Outer Membrane Proteins in Salmonella Enteritidis
Published on: January 27, 2021
11:10High-throughput Assay to Phenotype Salmonella enterica Typhimurium Association, Invasion, and Replication in Macrophages
Published on: August 11, 2014
Related Concept Videos
Gene Regulation in Microbial Communities: Quorum Sensing
Other Stress Responses in Bacteria
Global Regulatory Systems
Regulation of Bacterial Virulence
Formation of Lipopolysaccharides
Stringent Response in E. coli
