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Published on: April 17, 2021
Implementation of clinical pharmacy services in a pediatric dialysis unit
Radwa El Borolossy1, Lamia El Wakeel, Ihab El Hakim
1Department of Clinical Pharmacy, Faculty of Pharmacy, Ain Shams University, 4 street 292, New Maadi, New Maadi, Cairo, Egypt, radwa.maher14@yahoo.com.
Insights
Clinical pharmacist interventions significantly improved blood pressure, mineral levels, and treatment satisfaction in pediatric hemodialysis patients. This pharmaceutical care enhanced biochemical markers and patient well-being.
Area of Science:
- Nephrology
- Clinical Pharmacy
- Pediatric Medicine
Background:
- Patients with end-stage renal disease (ESRD) on hemodialysis often have complex medication regimens, increasing their risk of drug therapy-related problems (DTRPs).
- Children undergoing hemodialysis are particularly vulnerable to DTRPs due to intricate treatment plans.
Purpose of the Study:
- To identify DTRPs in pediatric hemodialysis patients.
- To evaluate the impact of clinical pharmacist interventions on the outcomes of these patients.
Main Methods:
- A 9-month study involving 50 pediatric hemodialysis outpatients divided into control and test groups.
- The test group received thrice-weekly pharmaceutical care alongside usual medical care, while the control group received only usual care.
Main Results:
- The test group demonstrated significant reductions in systolic and diastolic blood pressure, serum phosphorus, and parathyroid hormone levels.
- Serum calcium and calcium-x-phosphorus product levels improved significantly in the test group compared to the control.
- Patient satisfaction with renal treatment markedly increased in the test group.
Conclusions:
- Pharmacist-led pharmaceutical care interventions positively impacted biochemical parameters in pediatric hemodialysis patients.
- These interventions led to enhanced patient satisfaction and improved clinical outcomes.
Background:
End-stage renal disease patients on hemodialysis are on complex drug regimens consisting of multiple medications, many of which are administered in several doses per day. Consequently, such patients are at high risk for developing drug therapy-related problems (DTRPs). The aim of this study was to detect DTRPs in children undergoing hemodialysis and to assess and evaluate the impact of interventions by the clinical pharmacist on the clinical outcome of children undergoing hemodialysis.
Methods:
Fifty hemodialysis outpatients were randomly divided into two groups (25 each): the control group and the test group. During the 9-month study period, patients in the control group received the usual medical care, and those in the test group received pharmaceutical care 3 times weekly in addition to the usual medical care.
Results:
After 9 months of pharmaceutical care implementation, the test group showed a significant decline in systolic and diastolic blood pressure (p = 0.0001), serum phosphorus level (p = 0.006) and parathyroid hormone level (p = 0.001) versus their baseline values and versus the control. The serum Ca*P product level of the test group decreased (p = 0.001) after intervention versus baseline. Serum calcium level significantly increased in test group (p = 0.02) and decreased in the control group (p = 0.001) versus the respective baseline values. Satisfaction with the renal treatment significantly improved in the test group (p = 0.0001) versus the control group after 9 months of pharmaceutical care implementation based on Renal Treatment Satisfaction Questionnaire scores.
Conclusions:
Pharmacist-initiated pharmaceutical care improved the satisfaction and biochemical findings of patients on hemodialysis.
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