Related Experiment Video
Updated: May 3, 2026
08:30
Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
Published on: March 12, 2016
12.7K
Non-penetrating filtration surgery versus trabeculectomy for open-angle glaucoma
Mohamed A Eldaly1, Catey Bunce, Ola Z Elsheikha
1Ophthalmology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
The Cochrane Database of Systematic Reviews
|February 18, 2014
Summary
Trabeculectomy shows better intraocular pressure control than viscocanalostomy for glaucoma. Deep sclerectomy results are inconclusive, highlighting the need for more research on non-penetrating glaucoma surgery effectiveness and patient quality of life.
Area of Science:
- Ophthalmology
- Surgical Innovation
- Glaucoma Management
Background:
- Glaucoma is a leading cause of global blindness.
- Non-penetrating glaucoma surgeries offer a potentially safer alternative to conventional procedures.
Purpose of the Study:
- To compare the effectiveness of non-penetrating glaucoma surgery versus conventional trabeculectomy.
- To evaluate outcomes for viscocanalostomy and deep sclerectomy in glaucoma patients.
Main Methods:
- Systematic review of randomized controlled trials (RCTs) and quasi-RCTs.
- Searched multiple databases including CENTRAL, MEDLINE, EMBASE, LILACS, mRCT, ClinicalTrials.gov, and WHO ICTRP.
- Included studies comparing trabeculectomy with viscocanalostomy or deep sclerectomy.
Main Results:
- Trabeculectomy demonstrated better intraocular pressure (IOP) control compared to viscocanalostomy (OR 0.33, 95% CI 0.13 to 0.81).
- Effectiveness of deep sclerectomy was inconclusive.
- Non-penetrating surgery had fewer complications (17%) than trabeculectomy (65%), though cataract was more common after trabeculectomy.
- Methodological quality of included studies was generally low, with high risk of bias and incomplete reporting.
Conclusions:
- Limited evidence suggests trabeculectomy is superior to viscocanalostomy for IOP control in glaucoma.
- Further high-quality RCTs are needed to evaluate deep sclerectomy and non-penetrating glaucoma surgery (NPFS).
- Future trials should incorporate quality of life measures to assess the full impact of NPFS.
Related Concept Videos
01:28Angle Closure Glaucoma: Treatment
1.6K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.6K
01:27Open Angle Glaucoma: Treatment
1.1K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K
01:25Glaucoma: Overview
1.7K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.7K