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Related Experiment Video

Updated: May 3, 2026

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

Published on: June 8, 2020

Interval colorectal cancers: what and why.

Chantal M C le Clercq¹, Silvia Sanduleanu

¹Division of Gastroenterology and Hepatology, Department of Internal Medicine, Maastricht University Medical Center, Postbox 5800, 6202, AZ, Maastricht, The Netherlands, c.leclercq@maastrichtuniversity.nl.

Current Gastroenterology Reports

|February 18, 2014

Summary

Colonoscopy misses some colorectal cancers (CRC), particularly in the proximal colon. Improving detection of flat or serrated polyps and enhancing endoscopist training are crucial for reducing postcolonoscopy CRC.

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Area of Science:

Gastroenterology
Oncology
Endoscopy

Background:

Colonoscopy is a key tool for colorectal cancer (CRC) prevention.
However, interval CRCs (postcolonoscopy CRCs) occur, indicating limitations in colonoscopic surveillance.

Purpose of the Study:

To review the literature on postcolonoscopy CRC risk.
To identify common explanations for interval CRC occurrence.
To discuss implications for improving CRC prevention strategies.

Main Methods:

Literature review of studies on postcolonoscopy CRC.
Analysis of factors contributing to interval CRC, including missed lesions and polyp types.
Discussion of educational and training needs.

Main Results:

Missed lesions are the primary cause of postcolonoscopy CRC.
Nonpolypoid (flat/depressed) neoplasms and sessile serrated polyps are frequently missed.
Molecular events may increase cancer risk from these lesions.

Conclusions:

Colonoscopy is not infallible in preventing CRC, especially proximal tumors.
Enhanced training and detection techniques for subtle lesions are needed.
Addressing missed lesions is critical to reducing the burden of postcolonoscopy CRC.