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Pharmacokinetics of hydromorphone after intravenous, peroral and rectal administration to human subjects
P V Parab1, W A Ritschel, D E Coyle
1Division of Pharmaceutics and Drug Delivery Systems, University of Cincinnati Medical Center, Ohio 45267.
Abstract:
The pharmacokinetic properties of hydromorphone in healthy young male subjects were studied after i.v., peroral, and rectal administration. After i.v. administration the following pharmacokinetic parameters were found: elimination half-life 2.36 +/- 0.5 h, hepatic extraction ratio 0.51, apparent volume of distribution 2.9 +/- 1.3 L kg-1 and volume of central compartment 0.23 +/- 0.2 L kg-1. The absolute bioavailability after peroral administration was 50.7 +/- 29.8 per cent, and that after rectal administration was 33 +/- 22 per cent.
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