Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Glaucoma: Overview01:25

Glaucoma: Overview

1.7K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.7K
Photoreceptors and Visual Pathways01:22

Photoreceptors and Visual Pathways

8.5K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
8.5K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

1.1K
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
1.1K
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.6K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.6K
Disorders of the Nervous Tissue01:28

Disorders of the Nervous Tissue

3.0K
Nervous tissue is a vital component of the human body's communication system, enabling us to perceive and respond to stimuli. However, like all other tissues, it is vulnerable to disorders and diseases that can significantly impact our neurological functioning.
Homeostatic Imbalances:
Alzheimer's disease manifests as a gradual decline in memory and cognitive abilities, attributed to the buildup of amyloid plaques and neurofibrillary tangles in the brain.
Parkinson's disease arises from the...
3.0K
Increased Intracranial Pressure ll: Pathophysiology01:29

Increased Intracranial Pressure ll: Pathophysiology

20
Increased intracranial pressure (ICP) refers to a potentially life-threatening rise in pressure inside the skull. This usually happens when there is a major change in the volume of brain tissue, blood, or cerebrospinal fluid (CSF) — the three components inside the skull. According to the Monro-Kellie doctrine, if the volume of one component increases, the volumes of the other components must decrease to maintain normal pressure. If this does not happen, ICP rises.The process often begins...
20

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: An asymmetric fission island driven by shell effects in light fragments.

Nature·2025
Same author

Changes in fundus by optical coherence tomography in patients with chronic obstructive pulmonary disease: A systematic review.

The Medical journal of Malaysia·2025
Same author

An asymmetric fission island driven by shell effects in light fragments.

Nature·2025
Same author

First Proton-Induced Cross Sections on a Stored Rare Ion Beam: Measurement of ^{118}Te(p,γ) for Explosive Nucleosynthesis.

Physical review letters·2025
Same author

Nuclear Astrophysics in the Storage Ring: Background Suppressed Simultaneous Measurement of (p,γ) and (p,n) Reactions.

Physical review letters·2025
Same author

Shedding Light on the Origin of ^{204}Pb, the Heaviest s-Process-Only Isotope in the Solar System.

Physical review letters·2024

Related Experiment Video

Updated: May 3, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

12.7K

[Neurological disorders and glaucoma - an overview].

K Göbel1, C Erb2

  • 1Abteilung für Augenheilkunde, Schlosspark-Klinik, Berlin.

Klinische Monatsblatter Fur Augenheilkunde
|February 18, 2014
PubMed
Summary

Optic neuropathy, common in glaucoma, shares mechanisms with neurological diseases like Alzheimer's and Parkinson's. Research highlights shared biomarkers and pathogenic pathways, linking eye and brain health.

Area of Science:

  • Ophthalmology and Neurology
  • Neurodegenerative Diseases
  • Neuroscience

Context:

  • The optic nerve's proximity to the brain suggests a link between optic neuropathies and neurological disorders.
  • Glaucoma, a neurodegenerative disease, shares cellular and molecular pathways with other brain conditions.
  • Biomarkers for Alzheimer's disease are found in glaucoma patients' aqueous humor, and decreased cerebrospinal fluid pressure (CSFP) is noted in both.

Purpose:

  • To explore the association between neurological diseases and optic neuropathy in primary open-angle glaucoma.
  • To highlight common pathogenic mechanisms, including translaminar pressure difference, oxidative stress, and vascular factors.
  • To examine the impact of dopamine loss in Parkinson's disease on retinal function and structure.

Summary:

More Related Videos

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

1.7K
An Ex Vivo Explant Model for Studying Glial Interactions in the Mouse Retina
09:46

An Ex Vivo Explant Model for Studying Glial Interactions in the Mouse Retina

Published on: July 15, 2025

1.6K

Related Experiment Videos

Last Updated: May 3, 2026

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation
08:30

Glaucoma-inducing Procedure in an In Vivo Rat Model and Whole-mount Retina Preparation

Published on: March 12, 2016

12.7K
Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents
10:10

Full-Circle Cauterization of Limbal Vascular Plexus for Surgically Induced Glaucoma in Rodents

Published on: February 15, 2022

1.7K
An Ex Vivo Explant Model for Studying Glial Interactions in the Mouse Retina
09:46

An Ex Vivo Explant Model for Studying Glial Interactions in the Mouse Retina

Published on: July 15, 2025

1.6K
  • Primary open-angle glaucoma shares neurodegenerative pathways with Alzheimer's disease, evidenced by common biomarkers and reduced CSFP.
  • Parkinson's disease, characterized by dopamine neuron loss, affects vision through reduced visual acuity, color vision, and retinal nerve fiber layer thickness.
  • Shared factors like oxidative stress, excitotoxicity, mitochondrial dysfunction, genetics, and vascular issues contribute to optic neuropathy in glaucoma and neurological diseases.

Impact:

  • Establishes a stronger connection between ophthalmology and neurology, particularly in understanding glaucoma's broader neurodegenerative nature.
  • Suggests potential for shared diagnostic or therapeutic strategies for glaucoma and neurological conditions like Alzheimer's and Parkinson's.
  • Emphasizes the importance of considering systemic neurological health in managing optic neuropathies.