NFKB1 -94 insertion/deletion polymorphism and cancer risk: a meta-analysis
Linlin Xu1, Shaoyi Huang, Wei Chen
1Department of Clinical Laboratory, The First People's Hospital of Yancheng, Yancheng, Jiangsu, 224001, China, xulinlin1212@126.com.
Summary
The NFKB1 -94 insertion/deletion polymorphism is linked to increased cancer risk, particularly in Asian populations. This genetic variation may influence susceptibility to certain cancers, warranting further investigation.
Area of Science:
- Genetics
- Oncology
- Molecular Biology
Background:
- Conflicting results exist regarding the association between the NFKB1 -94 insertion/deletion polymorphism and cancer risk.
- The NFKB1 gene plays a crucial role in inflammatory and immune responses, potentially influencing cancer development.
Purpose of the Study:
- To conduct a comprehensive meta-analysis defining the effect of the NFKB1 -94 insertion/deletion polymorphism on overall cancer risk.
- To investigate ethnic and cancer-type specific associations with this polymorphism.
Main Methods:
- A systematic literature search was performed using PubMed to identify relevant studies.
- Twenty-three studies, including 6,494 cancer cases and 9,884 controls, were meta-analyzed under various genetic models.
Main Results:
- A significant overall association was observed between the NFKB1 -94 insertion/deletion polymorphism and cancer risk across all genetic models.
- Subgroup analyses revealed significant associations in the Asian population but not in the Caucasian population.
- Specific cancer types like oral cancer (OC), hepatocellular carcinoma (HCC), and oral squamous cell carcinoma (OSCC) showed significant associations, unlike breast cancer (BC) and lung cancer (LC).
Conclusions:
- The NFKB1 -94 insertion/deletion polymorphism is associated with cancer risk, with a notable impact observed in the Asian population.
- This genetic polymorphism may contribute to cancer susceptibility, particularly in specific ethnic groups and cancer types.
Related Concept Videos
02:26NF-κB-dependent Signaling Pathway
7.6K
The transcription factor NF-κB was discovered in 1986 in the lab of Nobel laureate Professor David Baltimore, for its interaction with the immunoglobulin light chain enhancer in B-cells. After more than three decades of study, it is now evident that NF-κB regulates the expression of over 100 genes. Most of these genes play an essential role in the innate and adaptive immune responses as well as the inflammatory responses of animals.
NF-κB-dependent Signaling Mechanism
The...
NF-κB-dependent Signaling Mechanism
The...
7.6K
03:18Non-LTR Retrotransposons
12.4K
As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
12.4K
01:20The Retinoblastoma Gene
3.7K
Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
3.7K
02:59Cancer Prevention
6.5K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.5K
01:33Cancer-Critical Genes I: Proto-oncogenes
9.1K
Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
9.1K
01:33Cancer-Critical Genes I: Proto-oncogenes
6.1K
6.1K