Cytotoxic potential of silver nanoparticles
Tianlu Zhang1, Liming Wang, Qiang Chen
1CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, National Center for Nanoscience and Technology, No. 11, Beiyitiao, Zhongguancun, Beijing100190, China. chenchy@nanoctr.cn.
Yonsei Medical Journal
|February 18, 2014
Summary
Silver nanoparticles (AgNPs) show antimicrobial properties but their safety is a concern. This review details AgNP effects on cells, including uptake, toxicity, and immune responses, aiding future risk assessments.
Area of Science:
- Nanotechnology
- Cell Biology
- Toxicology
Background:
- Silver nanoparticles (AgNPs) are prevalent in consumer and healthcare products due to their antimicrobial efficacy.
- Growing human exposure to AgNPs necessitates a thorough understanding of their safety profile.
- Recent studies highlight the need to evaluate the cellular-level impacts of AgNPs.
Purpose of the Study:
- To review and discuss the potential cellular impacts of silver nanoparticles (AgNPs).
- To identify key factors influencing AgNP effects on cells in vitro and in vivo.
- To summarize current knowledge and highlight challenges in AgNP risk assessment.
Main Methods:
- Literature review of recent scientific studies on AgNP-cell interactions.
- Analysis of data concerning AgNP uptake, distribution, cytotoxicity, genotoxicity, and immunological responses.
- Examination of factors influencing AgNP effects, including dose, time, size, shape, surface chemistry, and cell type.
Main Results:
- AgNPs interact with cells through uptake and intracellular distribution.
- AgNPs can induce cytotoxicity, genotoxicity, and modulate immunological responses.
- Factors such as dose, size, shape, surface chemistry, and cell type significantly influence AgNP effects.
Conclusions:
- AgNP effects on cells are multifaceted and depend on various parameters.
- Understanding these cellular influences is crucial for accurate risk assessment of AgNPs.
- Further research is needed to address existing challenges in AgNP safety evaluation.
Keywords:
Silver nanoparticlescell effectscytotoxicitygenotoxicityimmunological responserisk assessmentMore Related Videos
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