Related Experiment Video

Updated: May 3, 2026

Author Spotlight: A Neonatal Heterotopic Rat Heart Transplantation Model for the Study of Endothelial-to-Mesenchymal Transition
08:38

Author Spotlight: A Neonatal Heterotopic Rat Heart Transplantation Model for the Study of Endothelial-to-Mesenchymal Transition

Published on: July 21, 2023

1.7K

Neonatal tuberculosis and cardiac inflammatory myofibroblastic tumor

Maria Niña F Banque1, Ramon O Ribu, Maria Theresa T Policarpio

  • 1Division of Pulmonary and Critical Care Medicine, Section of Pediatric Pulmonology, Philippine Heart Center, Quezon City, Philippines.

Asian Cardiovascular & Thoracic Annals
|February 18, 2014
PubMed

Insights

A rare inflammatory myofibroblastic tumor in a neonate with respiratory distress resolved completely after antituberculosis medication. This case highlights tuberculosis as a potential cause of cardiac masses in infants.

Area of Science:

  • Pediatric Cardiology
  • Pediatric Oncology
  • Infectious Diseases

Background:

  • Inflammatory myofibroblastic tumors (IMTs) are rare neoplasms of uncertain malignant potential.
  • Cardiac IMTs are exceptionally rare, particularly in neonates, presenting diagnostic and therapeutic challenges.

Observation:

  • A 1-month-old neonate presented with respiratory distress and was found to have an anterior cardiac mass near the left ventricle and right ventricular outflow tract via echocardiography and CT scan.
  • Biopsy confirmed inflammatory myofibroblastic tumor. Concurrently, a positive tuberculin test and positive results in three household contacts indicated active tuberculosis.

Findings:

  • The patient received antituberculosis medication.
  • After one year of treatment, follow-up echocardiography and CT scans demonstrated complete resolution of the cardiac mass.

Implications:

  • This case suggests that tuberculosis should be considered in the differential diagnosis of cardiac masses in neonates, especially in endemic areas.
  • Successful treatment of tuberculosis led to the complete resolution of the inflammatory myofibroblastic tumor, indicating a potential infectious etiology for this tumor type in this specific context.

Keywords:
Granulomainfantnewbornplasma celltuberculosis

More Related Videos

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus06:15

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

Published on: March 6, 2019

53.3K
A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

5.5K

Related Concept Videos

Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
1.8K
Pulmonary Tuberculosis II01:28

Pulmonary Tuberculosis II

Tuberculosis, or TB, is a bacterial infectious disease caused by Mycobacterium tuberculosis. While its primary impact is on the lungs, leading to pulmonary tuberculosis, it can also affect various other organs, a condition referred to as extrapulmonary tuberculosis.
Here is a detailed explanation of its pathophysiology:
Transmission: The process begins when a person inhales droplet nuclei containing M. tuberculosis. These are typically released into the air when an individual with pulmonary or...
2.5K
Myocarditis I: Introduction01:21

Myocarditis I: Introduction

Myocarditis is inflammation of the myocardium, which is the muscular layer of the heart.EtiologyMyocarditis has a diverse etiology, including a wide range of infectious and non-infectious causes:Infectious CausesViral: Common viruses include Coxsackie A and B, adenovirus, parvovirus B19, enteroviruses, and influenza A.Bacterial: Examples include infections caused by Streptococcus, Staphylococcus, and Mycoplasma species.Rickettsial: Infections like Rocky Mountain spotted fever can result in...
645
Pulmonary Tuberculosis IV01:26

Pulmonary Tuberculosis IV

Tuberculosis, more commonly referred to as TB, is an infectious disease stemming from Mycobacterium tuberculosis. While it primarily impacts the lungs, TB can also affect other body areas. Given its severity and global impact, timely and accurate diagnosis is crucial for controlling its spread and improving patient outcomes.
Several diagnostic approaches are used to detect TB. The conventional method is the Tuberculin Skin Test (TST), also known as the Mantoux test. However, this method has...
828
Pulmonary Tuberculosis I01:29

Pulmonary Tuberculosis I

Tuberculosis, often called TB, is a contagious illness primarily caused by Mycobacterium tuberculosis. It mainly affects the lung parenchyma but can also impact other body parts.
Causative Organism
The primary infectious agent causing tuberculosis is Mycobacterium tuberculosis, a slow-growing, acid-fast, aerobic rod that exhibits sensitivity to heat and ultraviolet light. Instances of Mycobacterium bovis and Mycobacterium avium contributing to the development of TB infection are rare.
Mode of...
1.7K
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
493