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In vitro effect of a glycopeptide acting in vivo on hepatocyte cell cycle
M N Lombard1, C Nadal, M J Monnot
1Institut Curie, Biologie Centre Universitaire, Orsay, France.
Cell and Tissue Kinetics
|September 1, 1987
Abstract:
A factor specifically inhibiting the hepatocyte cell cycle in vivo was found to block the G1-S transition of liver cells in vitro. It proved to be non-toxic in our culture conditions, as judged by the reversibility of the effect on cell proliferation. It was not active on DNA synthesis in fibroblastic cell lines (3T3).