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Second-trimester induced abortions in two tertiary centres in Rome
Carlo Bastianelli1, Manuela Farris, Camilla Aliberti
1* Department of Gynaecology, Obstetrics, and Urology, Sapienza University , Rome , Italy.
Summary
Second-trimester induced abortions (STIAs) are increasingly common. Genetic anomalies, particularly trisomy 21, are the most frequent reasons for these pregnancy terminations.
Area of Science:
- Medical Science
- Obstetrics & Gynaecology
- Prenatal Diagnosis
Background:
- Rising demand for second-trimester induced abortions (STIAs) in Italy.
- Introduction of mifepristone in 2010, offering a new modality alongside prostaglandins.
- Limited research on the specific indications for STIAs.
Purpose of the Study:
- Compare prostaglandin-only versus mifepristone-inclusive methods for STIAs.
- Investigate and analyze the primary reasons women seek STIAs.
- Identify common fetal anomalies leading to pregnancy termination decisions.
Main Methods:
- Retrospective analysis of STIA records from two Roman institutions (2004-2012).
- Data collection included patient demographics, obstetric history, gestational age, and reasons for STIA.
- Evaluation of intervention methods and any recorded complications.
Main Results:
- 353 women requested STIAs during the study period.
- Genetic or karyotype anomalies cited in 53% of cases; structural anomalies in 45%.
- Ultrasound was the primary diagnostic tool for identifying these anomalies.
Conclusions:
- Genetic abnormalities are the predominant reason for STIAs.
- Trisomy 21 was the most frequently diagnosed chromosomal abnormality, accounting for 59% of cases.
- Further research is needed to understand the factors influencing STIA decisions.
