Related Experiment Video
Updated: May 3, 2026

A Platform of Anti-biofilm Assays Suited to the Exploration of Natural Compound Libraries
Published on: December 27, 2016
Antibacterial activity of thioetherhydroxyethylsulfonamide derivatives
Walcimar T Vellasco, Guilherme P Guedes, Victor Facchinetti
1Fundacao Oswaldo Cruz, Instituto de Tecnologia em Farmacos - Farmanguinhos. Rua Sizenando Nabuco 100, Manguinhos, Rio de Janeiro, 21041-250, RJ, Brazil. claudiabrandao@far.fiocruz.br.
Abstract:
Thioetherhydroxyethylsulfonamide derivatives were synthesized and evaluated for their in vitro antibacterial activity against Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853) and Staphylococcus aureus (ATCC 25923). Results have shown that compounds 8c and 9e display potent activity (MIC = 0.125 µg/mL) against E. coli when compared with the standard drug sulfamethoxazole (SMZ, MIC < 0.5 µg/mL) for this same strain. All the new compounds were fully identified and characterized by NMR ((1)H and (13)C) and X-ray crystallography (for compound 8c). This class of compounds can be considered as a good starting point for the development of new lead molecules in the fight against multi-drug bacterial resistance.
Related Concept Videos
Structure and Nomenclature of Thiols and Sulfides
Preparation and Reactions of Sulfides
Amines to Sulfonamides: The Hinsberg Test
Generally, a primary amine reacts with the Hinsberg reagent to produce an N-substituted benzenesulfonamide. The electron-withdrawing sulfonyl...
Antihypertensive Drugs: Thiazide-Class Diuretics
Antimicrobial Effectiveness
Preparation and Reactions of Thiols

