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Updated: Jul 24, 2026

The Importance of Correct Protein Concentration for Kinetics and Affinity Determination in Structure-function Analysis
Published on: March 17, 2010
[The protein C inhibitory system]
F Kase1, N W Spurling, J Pospísil
1Institut für Biophysik und Nuklearmedizin, medizinischen Fakultät, Karls-Universität, Praha/CSSR.
Abstract:
The chemical and physical characteristics of the individual components of the protein-C inhibiting system, protein C, thrombomodulin, protein S and the inhibitor of the activated protein C are summarized in a survey, with their mutual relations and their physiological impact on the course of the coagulating and fibrinolytic systems being represented. Finally, the clinical implications of a hereditary and acquired protein C deficiency, of a diminished protein S level and a lowered inhibitor of the activated protein C are discussed. The complications caused by a rapid decline of protein C values after administration of coumarin derivates are referred too.
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