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[The protein C inhibitory system].

F Kase1, N W Spurling, J Pospísil

  • 1Institut für Biophysik und Nuklearmedizin, medizinischen Fakultät, Karls-Universität, Praha/CSSR.

Folia Haematologica (Leipzig, Germany : 1928)
|January 1, 1987
PubMed
Summary

This survey details the protein C inhibiting system, including protein C, thrombomodulin, and protein S. It covers their roles in coagulation and fibrinolysis, and the clinical implications of deficiencies.

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Area of Science:

  • Biochemistry
  • Hematology
  • Physiology

Context:

  • The protein C inhibiting system is crucial for regulating blood coagulation and fibrinolysis.
  • Components include protein C, thrombomodulin, protein S, and the inhibitor of activated protein C.
  • Understanding these interactions is vital for comprehending hemostasis.

Purpose:

  • To summarize the chemical and physical characteristics of protein C inhibiting system components.
  • To represent their mutual relations and physiological impact on coagulation and fibrinolysis.
  • To discuss clinical implications of deficiencies and related complications.

Summary:

  • The survey outlines the properties of protein C, thrombomodulin, protein S, and their inhibitor.
  • It details their physiological roles in the coagulating and fibrinolytic systems.
  • Clinical implications of hereditary/acquired protein C deficiency, diminished protein S, and low inhibitor levels are discussed, along with coumarin-induced complications.

Impact:

  • Provides a comprehensive overview of the protein C inhibiting system for researchers and clinicians.
  • Highlights the clinical significance of protein C and protein S deficiencies.
  • Informs on potential complications associated with anticoagulant therapy, such as coumarin derivatives.

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