Related Experiment Video
Updated: May 3, 2026

Author Spotlight: Methodologies and Advancements of Chronic Pain Management Research
Published on: January 5, 2024
Decreased physical activity attributable to higher body mass index influences fibromyalgia symptoms
Ann Vincent1, Daniel Clauw2, Terry H Oh3
1Fibromyalgia and Chronic Fatigue Clinic, Mayo Clinic, 200 First Street SW, Rochester, MN 55902(∗).
Background:
Although previous studies report associations between increased body mass index (BMI) and fibromyalgia symptoms, there is uncertainty as to whether this relationship is driven by physical factors, psychological factors, or both.
Objective:
To assess these relationships in a clinical sample of patients with fibromyalgia.
Design:
Cross-sectional study.
Setting:
Tertiary care facility.
Patients:
A total of 686 patients from an existing national fibromyalgia registry.
Methods:
Patients completed a demographic form and self-report questionnaires including the Fibromyalgia Impact Questionnaire-Revised (FIQ-R), the Medical Outcomes Study Short Form-36 (SF-36), the Brief Pain Inventory (BPI), and the 30-item Profile of Mood States (30-item POMS).
Main Outcome Measurements:
FIQ-R overall impact subscale.
Results:
BMI was significantly correlated with fibromyalgia impact (P < .001). The relationship between BMI and fibromyalgia impact was almost fully accounted for by physical factors and not by psychological factors.
Conclusions:
Despite patient report that pain hinders physical activity, clinicians who encounter patients with fibromyalgia, particularly patients with increased BMI, should be cognizant of the need to invest time and resources to counsel patients on physical factors (ie, physical activity) that could improve the patients' symptom experience.
Related Concept Videos
Obesity
Layers of Connective Tissue Proper
Bone Disorders
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...
Pharmacokinetics in Obese Patients: Drug Absorption and Distribution
Disorders of the Skeletal Muscle
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...

