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A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
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Human renal clear cell carcinoma: establishment and characterization of a new cell line (G-2101)

P H Gumerlock1, B F Edwards, A D Deitch

  • 1University of California-Davis Medical Center, Department of Internal Medicine, Sacramento.

In Vitro Cellular & Developmental Biology : Journal of the Tissue Culture Association
|May 1, 1988
PubMed

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Cell Lines01:16

Cell Lines

A cell line is a population of cells grown in vitro that can be subcultured over several generations. Normal cells cease to divide after a certain number of cell divisions, a process known as replicative senescence. This number, called the Hayflick limit, was conceptualized by Leonard Hayflick in 1961 when he observed that fetal cells grown in culture could only divide 40-60 times. This limit is due to the shortening of the telomeres during each round of cell division, preventing cell division...