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An Adoptive Transfer Model of Rheumatoid Arthritis in Mice
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Emerging immunotherapies for rheumatoid arthritis

Gary Reynolds1, Faye A H Cooles1, John D Isaacs2

  • 1Institute of Cellular Medicine; Musculoskeletal Research Group; Newcastle University; Newcastle upon Tyne, Tyne and Wear UK.

Human Vaccines & Immunotherapeutics
|February 19, 2014
PubMed

Novel treatments in development for rheumatoid arthritis target 3 broad areas: cytokines, cells, and signaling pathways. Therapies from each domain share common advantages (for example previously demonstrated efficacy, potential long-term immunomodulation, and oral administration respectively) that have stimulated research in each area but also common obstacles to their development. In this review recent progress in each area will be discussed alongside the factors that have impeded their path to clinical use.

Keywords:
anti-chemokine therapyanti-cytokine therapybiologicscellular therapyimmunotherapyrheumatoid arthritissmall molecule inhibitors

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