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Related Experiment Video

Updated: May 3, 2026

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Syphilis masquerading as focal segmental glomerulosclerosis.

A J Hartley1, R Rajakariar2, M Sheaff2

  • 1Newham University Hospital, Barts Health NHS Trust, London, UK anna.hartley@bartshealth.nhs.uk.

International Journal of STD & AIDS
|February 19, 2014
PubMed
Summary
This summary is machine-generated.

Syphilis infection can cause nephrotic syndrome, a kidney disorder. Treatment with doxycycline significantly reduced proteinuria and improved albumin levels in a patient with syphilis-associated focal segmental glomerulosclerosis (FSGS).

Keywords:
Sexually transmitted infectionsTreponema pallidumdoxycyclinefocal segmental glomerulosclerosisglomerulonephritislatenephroticproteinuriarenalsyphilis

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Area of Science:

  • Nephrology
  • Infectious Diseases
  • Pathology

Background:

  • Syphilis serology can indicate infection.
  • Nephrotic syndrome presents with specific clinical signs.
  • Renal biopsy is crucial for diagnosing kidney diseases like FSGS.

Observation:

  • A patient presented with symptoms of nephrotic syndrome and positive syphilis serology.
  • Renal biopsy confirmed focal segmental glomerulosclerosis (FSGS).

Findings:

  • Treatment with doxycycline (200 mg twice daily for 28 days) led to a significant reduction in proteinuria.
  • Serum albumin levels increased considerably following doxycycline treatment.

Implications:

  • This suggests a potential causal link between syphilis and FSGS.
  • Doxycycline may be an effective treatment for syphilis-induced nephrotic syndrome.
  • Further research is warranted to confirm the efficacy of antibiotics in such cases.