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Manic episode following deep brain stimulation of the subthalamic nucleus for Parkinson's disease: a case report

Tugce Toker Ugurlu1, Goksemin Acar, Filiz Karadag

  • 1Pamukkale University, Faculty of Medicine, Department of Psychiatry, Denizli, Turkey.

Turkish Neurosurgery
|February 19, 2014
PubMed
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Parkinson disease (PD) is a progressive neurodegenerative disorder primarily affecting movement, with additional non-motor features. Its pathophysiology involves complex interactions among genetic susceptibility, environmental exposures, and cellular dysfunction, including dopaminergic neuron loss, protein aggregation, and mitochondrial impairment.Selective NeurodegenerationA key feature is the degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to reduced...
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