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Activation of the mas oncogene during transfection of monoblastic cell line DNA
J W Janssen1, A C Steenvoorden, M Schmidtberger
1Departments of Pediatrics II, University of Ulm, F.R.G.
Leukemia
|May 1, 1988
Abstract:
Using the tumorigenicity assay, we observed an activation of the mas oncogene during transfection of human acute myelocytic leukemia (CTV-2) DNA. Respective transfectants contained amplified mas sequences characterized by rearrangements in 5' and 3' noncoding regions that were transcribed into a 3.3 kb mas RNA species. Our data represent the second report on activation of the mas gene.