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Related Experiment Videos

Neutrophilic urticaria.

R K Winkelmann1, E Wilson-Jones, N P Smith

  • 1Department of Dermatology, Mayo Clinic, Rochester, Minnesota.

Acta Dermato-Venereologica
|January 1, 1988
PubMed
Summary
This summary is machine-generated.

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Neutrophilic urticaria, characterized by neutrophilic venulitis, shares features with chronic urticaria. All patients responded well to antihistamine treatment, suggesting a variant of this common skin condition.

Area of Science:

  • Dermatology
  • Immunology

Background:

  • Neutrophilic urticaria is a rare condition.
  • Previous diagnoses sometimes confused it with vasculitis.

Purpose of the Study:

  • To characterize neutrophilic urticaria.
  • To differentiate it from vasculitis.
  • To evaluate treatment responses.

Main Methods:

  • Retrospective review of eight patients diagnosed with neutrophilic urticaria over five years (1980-1984).
  • Histopathological analysis of skin biopsies.
  • Review of clinical histories, laboratory results, and treatment outcomes.

Main Results:

  • All eight patients exhibited neutrophilic venulitis without key vasculitic markers.

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  • Associated conditions included angioedema and atopic disease in some patients.
  • Laboratory tests for complement, proteins, and antibodies were normal.
  • All patients showed positive response to antihistamine therapy.

    • Conclusions:

    • Neutrophilic urticaria presents with specific histopathological findings distinct from vasculitis.
    • Clinical and laboratory features align with a form of chronic urticaria.
    • Antihistamines are an effective treatment modality.